Benedict is a senior advisor to the Bulletin of the Atomic Scientists and served as Executive Director and Publisher from 2005 until she retired in February 2015. She is a Lecturer at the Harris School of Public Policy at the University of Chicago.
Previously, Benedict was the Director of International Peace and Security at the John D. and Catherine T. MacArthur Foundation, overseeing grant-making on a broad international security agenda, as well as supporting efforts to reduce the threat from weapons of mass destruction and an initiative on science, technology, and security.
Benedict has taught at the University of Illinois at Urbana-Champaign, and at Rutgers University, New Brunswick. She has published numerous columns and articles about nuclear weapons and disarmament, nuclear power, climate change, and global governance, and has made many media appearances regarding those issues. Benedict received her BA from Oberlin College and her PhD in political science from Stanford University.