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Nuzzo is a senior associate at the Univesity of Pittsburg Medical Center's Center for Health Security (formerly the Center for Biosecurity of UPMC). An epidemiologist by training, Nuzzo focuses her work on improving biosurveillance and outbreak management in the United States and around the world. She is also an associate editor of the peer-reviewed journal, Biosecurity and Bioterrorism: Biodefense Strategy, Practice, and Science.